TY  - JOUR
T1  - Role of oxidative stress in liver cancer
A1  - Hossein Forouzandeh
A1  - Heibatullah Kalantari
A1  - Najmaldin Saki
A1  - Zahra Foruozandeh
A1  - Ehsan Arefian
A1  - Abbas Farahani
A1  - Ghasem Hassani
A1  - Mohammad Bazrafshan
A1  - Shima Rasouli
JF  - Clinical Cancer Investigation Journal
JO  - Clin Cancer Investig J
SN  - 2278-0513
Y1  - 2017
VL  - 6
IS  - 1
DO  - 10.4103/ccij.ccij_176_16
SP  - 1
EP  - 9
N2  - The present article provides an overview of the role of oxidative stress in the development and progression of liver cancer (LC). Oxidative stress ensues when the balance between the production of reactive oxygen species (ROS) and reactive nitrogen species overrides the antioxidant defense of the target cell and body fails in detoxifying their harmful effects. Therefore, the interaction of these reactive species with critical cellular macromolecules may cause oxidative damage. Moreover, ROS may interact with cellular components including proteins, lipids, and DNAs, which results in altered target cell function. The accumulation of oxidative damage products has been implicated in both acute and chronic cell injury suggesting a possible role in the pathogenesis of Parkinson's disease, Alzheimer's disease, atherosclerosis, heart failure, myocardial infarction, and cancers. Alcoholism, viral agents, obesity, and smoking increase the occurrence of oxidative stress and consequently the risk of LC.
UR  - https://ccij-online.org/article/role-of-oxidative-stress-in-liver-cancer-672
ER  -