TY  - JOUR
T1  - Retinal detachment as the inaugural manifestation in Waldenstrom′s macroglobulinemia
A1  - Hanumanthappa Raghavendra
A1  - Namrata Rajkumar
A1  - Lakshmaiah Chinnagiriyappa
A1  - Visweswariah Devi
JF  - Clinical Cancer Investigation Journal
JO  - Clin Cancer Investig J
SN  - 2278-0513
Y1  - 2015
VL  - 4
IS  - 3
DO  - 10.4103/2278-0513.154536
SP  - 435
EP  - 437
N2  - Waldenstrom′s macroglobulinemia (WM) is a rare disorder and forms 1-2% of hematological malignancies. Rarely retinal detachment precedes the diagnosis of WM. In this case report, we present 65-year-old man with retinal detachment as the inaugural manifestation in WM. Clinical manifestations in WM are related to direct tumor infiltration, circulating immunoglobulin M (IgM) and deposition into tissues, amyloidogenic properties and autoantibody activity of IgM. Diagnosis is difficult, when a rare disease manifests differently, as in our case. Delay in diagnosis can be prevented by heightened awareness of this rare disease.
UR  - https://ccij-online.org/article/retinal-detachment-as-the-inaugural-manifestation-in-waldenstrom′s-macroglobulinemia-415
ER  -