%0 Journal Article
%T Retinal detachment as the inaugural manifestation in Waldenstrom′s macroglobulinemia
%A Hanumanthappa Raghavendra
%A Namrata Rajkumar
%A Lakshmaiah Chinnagiriyappa
%A Visweswariah Devi
%J Clinical Cancer Investigation Journal
%@ 2278-0513
%D 2015
%V 4
%N 3
%R 10.4103/2278-0513.154536
%P 435-437
%X Waldenstrom′s macroglobulinemia (WM) is a rare disorder and forms 1-2% of hematological malignancies. Rarely retinal detachment precedes the diagnosis of WM. In this case report, we present 65-year-old man with retinal detachment as the inaugural manifestation in WM. Clinical manifestations in WM are related to direct tumor infiltration, circulating immunoglobulin M (IgM) and deposition into tissues, amyloidogenic properties and autoantibody activity of IgM. Diagnosis is difficult, when a rare disease manifests differently, as in our case. Delay in diagnosis can be prevented by heightened awareness of this rare disease.
%U https://ccij-online.org/article/retinal-detachment-as-the-inaugural-manifestation-in-waldenstrom′s-macroglobulinemia-415