TY  - JOUR
T1  - Primary amelanotic melanoma of the cervix: A case report with review of literature
A1  - Lalita Negi
A1  - Kavita Mardi
A1  - Liza Negi
JF  - Clinical Cancer Investigation Journal
JO  - Clin Cancer Investig J
SN  - 2278-0513
Y1  - 2020
VL  - 9
IS  - 6
DO  - 10.4103/ccij.ccij_95_20
SP  - 264
EP  - 266
N2  - 
Primary malignant melanoma arising from the uterine cervix is extremely rare. It may be misdiagnosed, especially when amelanotic, in which case immunohistochemistry is useful in reaching the diagnosis. We present a case of 67-year-old postmenopausal patient presenting with bleeding per vaginum. Per speculum examination revealed an ulceroproliferative growth involving the cervix. Microscopic examination showed sheets of pleomorphic cells with prominent eosinophilic nucleoli and intranuclear inclusion. On histopathological examination, possibilities of poorly differentiated carcinoma and amelanotic melanoma were kept. On immunohistochemical analysis, tumor cells were strongly positive for HMB-45, S-100, and vimentin. Keeping in view the histopathological and immunohistochemical findings, diagnosis of amelanotic melanoma of cervix was given. Pertinent literature is also reviewed.

UR  - https://ccij-online.org/article/primary-amelanotic-melanoma-of-the-cervix:-a-case-report-with-review-of-literature-876
ER  -