TY  - JOUR
T1  - Nanogoldtechnology-imaging, sensing and target therapy in head and neck cancer
A1  - Nishat Sultana
A1  - Suraksha Shenoy
A1  - M Sham
A1  - Shilpa Keshav
A1  - Rachna Kaul
JF  - Clinical Cancer Investigation Journal
JO  - Clin Cancer Investig J
SN  - 2278-0513
Y1  - 2012
VL  - 1
IS  - 1
DO  - 10.4103/2278-0513.95012
SP  - 6
EP  - 12
N2  - Innovation in the last decade has endowed nanotechnology with an assortment of tools for delivery, imaging, and sensing in cancer research. Cancer nanotherapeutics are rapidly progressing and are being implemented to solve several limitations of conventional drug delivery systems such as nonspecific biodistribution and targeting, lack of water solubility, poor oral bioavailability, and low therapeutic indices. To improve the biodistribution of cancer drugs, nanoparticles have been designed for optimal size and surface characteristics to increase their circulation time in the bloodstream. Nanoparticles have the ability to accumulate in cells without being recognized by P-glycoprotein, one of themainmediators of multidrug resistance, resulting in the increased intracellular concentration of drugs. Multifunctional and multiplex nanoparticles are now being actively investigated and are on the horizon as the next generation of nanoparticles, facilitating personalized and tailored cancer treatment.
UR  - https://ccij-online.org/article/nanogoldtechnology-imaging,-sensing-and-target-therapy-in-head-and-neck-cancer-11
ER  -