TY  - JOUR
T1  - Monophasic synovial sarcoma of the tongue in an elderly lady: A diagnostic dilemma
A1  - Sharmila Dudani
A1  - Ajay Malik
A1  - Kavita Sahai
A1  - Madhurjya Barman
JF  - Clinical Cancer Investigation Journal
JO  - Clin Cancer Investig J
SN  - 2278-0513
Y1  - 2015
VL  - 4
IS  - 2
DO  - 10.4103/2278-0513.152750
SP  - 286
EP  - 288
N2  - Synovial sarcoma (SS) is a morphologically characteristic sarcoma of uncertain lineage, typically containing both epithelial and mesenchymal elements. The most common location is the extremities, and very few cases have been reported from the head and neck region. The monophasic spindle cell variant often poses a diagnostic challenge as it mimics poorly differentiated carcinoma or sarcoma. We report a case of monophasic SS of tongue in a 74-year-old female. On Immunohistochemistry, the tumor cells showed strong, diffuse positivity for vimentin, Bcl-2, CD99, and focal positivity for epithelial membrane antigen. Tumor cells were negative for pan cytokeratin, smooth muscle actin, S100, HMB-45, CD34. A high index of clinical suscipicion is required to reach an accurate diagnosis for institution of appropriate therapy.
UR  - https://ccij-online.org/article/monophasic-synovial-sarcoma-of-the-tongue-in-an-elderly-lady:-a-diagnostic-dilemma-374
ER  -