TY  - JOUR
T1  - Liquid Biopsy to the Rescue of Oral Cancer Diagnostics- A Narrative Review
A1  - Deeksha Anil Gandhi
A1  - Afiya Memon
A1  - Supriya Kheur
JF  - Clinical Cancer Investigation Journal
JO  - Clin Cancer Investig J
SN  - 2278-0513
Y1  - 2023
VL  - 12
IS  - 6
DO  - 10.51847/zwbQR2I4Gl
SP  - 14
EP  - 18
N2  - Oral cancer is a malignant tumor that arises from the tissues of the oral cavity. It is the eighth most common cancer worldwide, with a high mortality rate due to late-stage diagnosis. Traditional histological investigation is the gold standard for oral cancer diagnosis, but it is invasive and requires tissue biopsy. Liquid biopsy, a non-invasive approach, has emerged as a promising diagnostic technique for oral cancer in recent years. This technique examines tumors and their microenvironment by utilizing biomaterials found in bodily fluids such as blood, saliva, breast milk, and urine. The molecular cargo in liquid biopsy of malignant tumors include circulating tumor DNA(ctDNA), Exosomes, Circulating tumour cells (CTC), Micro RNA(miRNA) and cell free DNA. The use of liquid biopsy as a noninvasive method for early cancer detection, molecular profiling, treatment response monitoring, and detecting minimal residual disease holds great promise. This paper provides an overview of liquid biopsy as a diagnostic technique for oral cancer, focusing on its advantages, molecular candidates, and clinical applications.
UR  - https://ccij-online.org/article/liquid-biopsy-to-the-rescue-of-oral-cancer-diagnostics-a-narrative-review-ppvfz5pm7oruh74
ER  -