TY  - JOUR
T1  - Increased visceral adipose tissue in male patients with clear cell renal cell carcinoma
A1  - Federico Greco
A1  - Vincenzo Cirimele
A1  - Carlo Mallio
A1  - Bruno Zobel
A1  - Rosario Grasso
JF  - Clinical Cancer Investigation Journal
JO  - Clin Cancer Investig J
SN  - 2278-0513
Y1  - 2018
VL  - 7
IS  - 4
DO  - 10.4103/ccij.ccij_62_18
SP  - 132
EP  - 136
N2  - 
Background: Excessive accumulation of adipose tissue, mainly visceral, can determine adipocyte- and adipose tissue-related disorder. Visceral adipocytes secrete mediators associated with carcinogenesis. Several studies have shown a correlation between blood levels of these mediators and clear cell renal cell carcinoma (ccRCC). Indeed, specific biomarkers, including adipokines, have been considered as a possible link between obesity and RCC. Objective: The objective of the study is to test the hypothesis that there is an increase of visceral adipose tissue (VAT) in male patients with ccRCC. Methods: In this retrospective study, two groups were included: A group of patients with ccRCC and a control group without a history of malignancies. Total adipose tissue (TAT) area, VAT area, and subcutaneous adipose tissue (SAT) area were measured in both groups. VAT/SAT ratio was subsequently calculated. Results: Statistically significant differences between the two groups were found in VAT area (P = 0.01) and VAT/SAT ratio (P < 0.05), while no significant difference was found in TAT area and SAT area. Conclusions: This study shows an increased VAT in male patients with ccRCC.

UR  - https://ccij-online.org/article/increased-visceral-adipose-tissue-in-male-patients-with-clear-cell-renal-cell-carcinoma-747
ER  -