%0 Journal Article
%T High ezrin immunoreactivity is an indicator of poor survival in squamous cell carcinoma of uterine cervix
%A Tahany Shams
%A Hanaa Badr-El-Din
%A Iman Loay Abulkheir
%J Clinical Cancer Investigation Journal
%@ 2278-0513
%D 2012
%V 1
%N 1
%R 10.4103/2278-0513.95014
%P 16-22
%X Context: Ezrin, the membrane-linking protein, is highly expressed in several types of human cancers, and correlations between its immunoreactivity and histopathological data as well as patient outcome have previously been shown. Aims: The aim of our study was to investigate the expression of ezrin in cases of cervical squamous cell carcinoma, then correlate the data with survival and other clinicopathological variables. Materials and Methods: We carried out immunohistochemical analysis of ezrin in 64 cases of cervical cancer and correlated it to clinicopathologic variables and disease outcome. Results: Ezrin was identified in 50 (78.1%) of 64 studied cervical cancer cases, which was classified as weak, moderate and marked in 16%, 28% and 56%, respectively. In contrast to the predominantly membranous immunoreactivity in normal cervical epithelium, it was cytoplasmic in cancer cells. Ezrin expression significantly correlated with lymph node metastasis and development of distant metastasis (P
%U https://ccij-online.org/article/high-ezrin-immunoreactivity-is-an-indicator-of-poor-survival-in-squamous-cell-carcinoma-of-uterine-cervix-2