TY  - JOUR
T1  - Gliomas: Analysis of disease characteristics, treatment timelines and survival rates from two tertiary care hospitals of India
A1  - Hari Mukundan
A1  - Sankalp Singh
A1  - Nishant Lohia
A1  - Sachin Taneja
A1  - Arti Sarin
A1  - Sharad Bhatnagar
A1  - Pradeep Jaiswal
A1  - Gaurav Trivedi
A1  - Manoj Prasher
A1  - Sundaram Viswanath
JF  - Clinical Cancer Investigation Journal
JO  - Clin Cancer Investig J
SN  - 2278-0513
Y1  - 2020
VL  - 9
IS  - 4
DO  - 10.4103/ccij.ccij_27_20
SP  - 145
EP  - 154
N2  - 
Context: Gliomas are a heterogeneous group of relatively rare cancers that have an important public health-care implication due to their high levels of mortality and morbidity. While standard management guidelines are available, their implementation in a resource-limited scenario needs greater scrutiny. Settings and Design: This is a retrospective analysis of disease characteristics, treatment parameters including the time to imaging and time to treatment, and overall survival (OS) at 1 and 5 years in patients of brain gliomas. Subjects and Methods: Demographic, clinical, and follow-up data of histologically proven glioma patients that received radiotherapy (RT) between 2009 and 2013 at two tertiary care hospitals of India were collected and analyzed. Statistical Analysis: Kaplan–Meier curves were used to compare OS at 12 and 60 months. Cross-tabulation and Pearson's Chi-square test were used to study the association of study variables with survival. Results: One hundred and nine patients were included. The mean age was 45 years and males were three times as common as females. Astrocytomas were the most common histology with Grade IV astrocytomas comprising 48% of the total. The OS at 12 and 60 months was 79.8% and 24%, respectively, for the entire cohort. The average time taken for brain imaging from onset of symptoms was 24 days, while the time to surgery and the time to start RT were 18 and 44 days, respectively. Old age and ability to tolerate treatment were shown to affect survival at 1 year from diagnosis, though tumor histology and grade had an apparent impact on long-term prognosis. Conclusions: Hospital registries are an important source of demographic and clinical information on less common cancers such as gliomas. Increasing awareness among the general public and sensitization of primary health-care apparatus are critical for early diagnosis and treatment.

UR  - https://ccij-online.org/article/gliomas:-analysis-of-disease-characteristics,-treatment-timelines-and-survival-rates-from-two-tertiary-care-hospitals-of-india-852
ER  -