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An official publication of the Middle-Eastern Association for Cancer Research
Clinical Cancer Investigation Journal
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Year: 2023   |   Volume: 12   |   Issue: 1   |   Page: 17-26     View issue

Giant Cells Lesions of Oral and Maxillofacial Region – A Proposed Diagnostic Algorithm

Harpreet Kaur1, Deepika Mishra1*, Ajoy Roychoudhury2, Mehar Chand Sharma3, Ashu Seith Bhalla4, Asit Ranjan Mridha3, Aanchal Kakkar3, Rahul Yadav2, Sunny Kala1, Shashwat Mishra5

1Department of Oral Pathology and Microbiology, Centre for Dental Education and Research, All India Institute of Medical Sciences, Delhi, India. 2Department of Oral and Maxillofacial Surgery, Centre for Dental Education and Research, All India Institute of Medical Sciences, Delhi, India. 3Department of Pathology, All India Institute of Medical Sciences, Delhi, India. 4Department of Radiodiagnosis, All India Institute of Medical Sciences, Delhi, India. 5Department of Neurosurgery, All India Institute of Medical Sciences, Delhi, India.


Multinucleated giant cells are commonly encountered in histopathology and are mostly a clue to diagnosis but sometimes pose a diagnostic confusion. The present study elucidates a case series of giant cell lesions (GCL) with emphasis on differential diagnosis and other investigations that contribute towards arriving at a final diagnosis. We also intended to devise an algorithmic approach for the accurate pathological characterization of these lesions. All the cases reported in the department from January 2018 to June 2019 were reviewed by pathologists and the total number of lesions where giant cells were diagnostic or an additional finding were included in this study. Twenty-five cases out of 1000 biopsies were diagnosed based on giant cell morphology. The most frequent lesions were central giant cell granuloma, followed by cherubism, hyperparathyroidism, peripheral giant cell granuloma, tuberculosis, and hybrid lesion. A systematic approach towards differential diagnosis for such cases and a diagnostic algorithm was devised which is being followed as per the reported spectrum of GCL. Radiological, serology, and sometimes ancillary staining techniques are essential for the accurate histopathological diagnosis of giant cell lesions. Our diagnostic algorithm helps narrow down the spectrum of investigations necessary to characterize these lesions, enabling for a swifter and more confident identification of the pathologies.

Keywords: Multinucleated giant cells, Histopathology, Central giant cell lesions, Jaws, Oral and maxillofacial gegion



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