TY  - JOUR
T1  - Dual kappa and lambda expressing in mature B-cell neoplasm: An unusual case
A1  - Ashish Gupta
A1  - Deepak Mishra
A1  - Mammen Chandy
JF  - Clinical Cancer Investigation Journal
JO  - Clin Cancer Investig J
SN  - 2278-0513
Y1  - 2015
VL  - 4
IS  - 1
DO  - 10.4103/2278-0513.149062
SP  - 96
EP  - 98
N2  - A 57 years old male presented with transfusion dependent anemia for last 2 months with mild weight loss and on and off fever. On examination he was found to have small axillary lymph nodes with moderate splenomegaly. Flow cytometry revealed 63.2% cells in the lymphocyte window in cluster of differentiation (CD) 45 versus side scatter plot. Further analysis on CD-19 gated cells showed that - 75.9% of these cells expressed CD-19 plus the expression of CD23, CD25, CD43, CD20 and CD22. The entire cluster showed dual expression of kappa and lambda light chains. Final diagnosis of low-grade B non-Hodgkin lymphoma was made. Given that dual kappa and lambda expressing in mature B cell neoplasm has been described in literature, it is important to differentiate such cases from reactive lymphoid proliferations.
UR  - https://ccij-online.org/article/dual-kappa-and-lambda-expressing-in-mature-b-cell-neoplasm:-an-unusual-case-332
ER  -