%0 Journal Article
%T Dual kappa and lambda expressing in mature B-cell neoplasm: An unusual case
%A Ashish Gupta
%A Deepak Mishra
%A Mammen Chandy
%J Clinical Cancer Investigation Journal
%@ 2278-0513
%D 2015
%V 4
%N 1
%R 10.4103/2278-0513.149062
%P 96-98
%X A 57 years old male presented with transfusion dependent anemia for last 2 months with mild weight loss and on and off fever. On examination he was found to have small axillary lymph nodes with moderate splenomegaly. Flow cytometry revealed 63.2% cells in the lymphocyte window in cluster of differentiation (CD) 45 versus side scatter plot. Further analysis on CD-19 gated cells showed that - 75.9% of these cells expressed CD-19 plus the expression of CD23, CD25, CD43, CD20 and CD22. The entire cluster showed dual expression of kappa and lambda light chains. Final diagnosis of low-grade B non-Hodgkin lymphoma was made. Given that dual kappa and lambda expressing in mature B cell neoplasm has been described in literature, it is important to differentiate such cases from reactive lymphoid proliferations.
%U https://ccij-online.org/article/dual-kappa-and-lambda-expressing-in-mature-b-cell-neoplasm:-an-unusual-case-332