TY  - JOUR
T1  - Coexistence of ten-eleven translocation 2 and calreticulin mutations in myeloproliferative neoplasms: Possible prognostic value
A1  - Soheila Bagherpour
A1  - Tina Vosoughi
A1  - Maryam Birgani
A1  - Ali Ehsanpour
A1  - Najmaldin Saki
JF  - Clinical Cancer Investigation Journal
JO  - Clin Cancer Investig J
SN  - 2278-0513
Y1  - 2020
VL  - 9
IS  - 3
DO  - 10.4103/ccij.ccij_114_19
SP  - 84
EP  - 88
N2  - 
Background: Mutations in the genes regulating epigenetic factors such as Ten-Eleven Translocation 2 (TET2) along with other mutations are highly effective in the patient's prognosis. The aim of this study was to evaluate the prevalence of TET2 and calreticulin (CALR) mutations among myeloproliferative neoplasms (MPNs) patients to determine if there is a prognostic value for these mutations coexistence. Materials and Methods: Blood sample was collected from patients. For the evaluation of mutations, polymerase chain reaction (PCR) was performed on the patient's DNA and PCR products were subsequently sequenced. Results: No significant correlation between coexistence of TET2 and CALR mutations with complete blood count parameters in patients was seen. However, platelet count was lower in patients with TET2 and CALR mutations compared with patients with CALR mutations only. Conclusion: The coexistence of CALR and TET2 mutations in MPN patients can be used as a prognostic factor.

UR  - https://ccij-online.org/article/coexistence-of-ten-eleven-translocation-2-and-calreticulin-mutations-in-myeloproliferative-neoplasms:-possible-prognostic-value-842
ER  -