TY  - JOUR
T1  - Cancerogenesis in colorectal neoplasms: Evidence from early onset colorectal cancer
A1  - Mahsa Molaei
A1  - Babak Mansoori
A1  - Somayeh Ghiasi
A1  - Fatemeh Nemati
A1  - Shohreh Almasi
A1  - Seyed Fatemi
A1  - Ali Motlagh
A1  - Mohammad Zali
JF  - Clinical Cancer Investigation Journal
JO  - Clin Cancer Investig J
SN  - 2278-0513
Y1  - 2012
VL  - 1
IS  - 2
DO  - 10.4103/2278-0513.99562
SP  - 57
EP  - 64
N2  - Objective: Majority of colorectal cancers (CRC) happen via two distinct mechanisms of genomic instability: chromosomal and microsatellite instability. The proportion to which colorectal cancers belong to these pathways is well addressed in literature. However, there is much paucity and controversy regarding this proportion in early onset CRC; therefore, in the present study, major proteins involved in chromosomal and microsatellite instability pathways were determined in 104 early-onset CRC specimens. Materials and Methods: Outcome measures comprised expression of 4 mismatch repair (MMR) proteins (MLH1, MSH2, MSH6, PMS2), and two representative proteins of chromosomal instability pathway (P53 and β-catenin), which were determined by immunohistochemistry. Results: Twenty-nine cases (27.9%) had loss of expression of MMR proteins, of which 17 belonged to MutSα pathway and 12 to MutLα. Four tumors had solitary loss of PMS2. Tumors with abnormal MMR status were more likely to be right sided, and occurred mainly in familial setting (P
UR  - https://ccij-online.org/article/cancerogenesis-in-colorectal-neoplasms:-evidence-from-early-onset-colorectal-cancer-18
ER  -