%0 Journal Article
%T Cancerogenesis in colorectal neoplasms: Evidence from early onset colorectal cancer
%A Mahsa Molaei
%A Babak Mansoori
%A Somayeh Ghiasi
%A Fatemeh Nemati
%A Shohreh Almasi
%A Seyed Fatemi
%A Ali Motlagh
%A Mohammad Zali
%J Clinical Cancer Investigation Journal
%@ 2278-0513
%D 2012
%V 1
%N 2
%R 10.4103/2278-0513.99562
%P 57-64
%X Objective: Majority of colorectal cancers (CRC) happen via two distinct mechanisms of genomic instability: chromosomal and microsatellite instability. The proportion to which colorectal cancers belong to these pathways is well addressed in literature. However, there is much paucity and controversy regarding this proportion in early onset CRC; therefore, in the present study, major proteins involved in chromosomal and microsatellite instability pathways were determined in 104 early-onset CRC specimens. Materials and Methods: Outcome measures comprised expression of 4 mismatch repair (MMR) proteins (MLH1, MSH2, MSH6, PMS2), and two representative proteins of chromosomal instability pathway (P53 and β-catenin), which were determined by immunohistochemistry. Results: Twenty-nine cases (27.9%) had loss of expression of MMR proteins, of which 17 belonged to MutSα pathway and 12 to MutLα. Four tumors had solitary loss of PMS2. Tumors with abnormal MMR status were more likely to be right sided, and occurred mainly in familial setting (P
%U https://ccij-online.org/article/cancerogenesis-in-colorectal-neoplasms:-evidence-from-early-onset-colorectal-cancer-18