TY  - JOUR
T1  - Cancer stem cells: Recent advances, signaling and molecular markers
A1  - N Raj Kumar
A1  - Bina Kashyap
A1  - Arun Bhupathi
A1  - Ghanta Babu
A1  - A Nagaraja
A1  - Smita Birajdar
JF  - Clinical Cancer Investigation Journal
JO  - Clin Cancer Investig J
SN  - 2278-0513
Y1  - 2014
VL  - 3
IS  - 3
DO  - 10.4103/2278-0513.132106
SP  - 189
EP  - 195
N2  - Cancer stem cells (CSCs) are tumor cells with stem-like features that possess the ability to self-renew, but can also give rise to more differentiated progeny. CSC can be identified based on increased in vitro spheroid- or colony formation, enhanced in vivo tumor initiating potential, or expression of cell surface markers. Since CSCs are thought to be required for the maintenance of a tumor cell population, these cells could possibly serve as a therapeutic target. Therapeutics based on CSC markers, epithelial mesenchymal transition, developmental pathways, or tumor micro-environment could potentially be used to target CSC which may lead to a reduction of tumor growth, metastatic events and chemoresistance in various cancers.
UR  - https://ccij-online.org/article/cancer-stem-cells:-recent-advances,-signaling-and-molecular-markers-206
ER  -