%0 Journal Article
%T Cancer stem cells: Recent advances, signaling and molecular markers
%A N Raj Kumar
%A Bina Kashyap
%A Arun Bhupathi
%A Ghanta Babu
%A A Nagaraja
%A Smita Birajdar
%J Clinical Cancer Investigation Journal
%@ 2278-0513
%D 2014
%V 3
%N 3
%R 10.4103/2278-0513.132106
%P 189-195
%X Cancer stem cells (CSCs) are tumor cells with stem-like features that possess the ability to self-renew, but can also give rise to more differentiated progeny. CSC can be identified based on increased in vitro spheroid- or colony formation, enhanced in vivo tumor initiating potential, or expression of cell surface markers. Since CSCs are thought to be required for the maintenance of a tumor cell population, these cells could possibly serve as a therapeutic target. Therapeutics based on CSC markers, epithelial mesenchymal transition, developmental pathways, or tumor micro-environment could potentially be used to target CSC which may lead to a reduction of tumor growth, metastatic events and chemoresistance in various cancers.
%U https://ccij-online.org/article/cancer-stem-cells:-recent-advances,-signaling-and-molecular-markers-206