TY  - JOUR
T1  - Analysis of Interaction between Twenty-Seven Pyrimidinone Derivatives with XIAP Using a Theoretical Model
A1  - Lauro Figueroa-Valverde
A1  - Francisco Diaz-Cedillo
A1  - Marcela Rosas-Nexticapa
A1  - Catalina Cervantes-Ortega
A1  - Magdalena Alvarez-Ramirez
A1  - Virginia Mateu-Armand
A1  - Maria Lopez-Ramos
JF  - Clinical Cancer Investigation Journal
JO  - Clin Cancer Investig J
SN  - 2278-0513
Y1  - 2023
VL  - 12
IS  - 3
DO  - 10.51847/2bWWpF0Bdl
SP  - 13
EP  - 18
N2  - For several years, several drugs have been used to treat different types of cancer; however, some of these drugs can cause side effects, such as high blood pressure, liver damage, and erectile dysfunction. In the search for new therapeutic alternatives, some compounds have been developed for the treatment of this clinical pathology; however, the interaction of these drugs with some biomolecules involved in the development of cancer is very unclear. Analyzing this data, this investigation aimed to evaluate the possible theoretical interaction of some pyrimidinone derivatives (compounds 1 to 27) on the X-linked inhibitor of apoptosis protein (XIAP) involved in cancer using the Docking model. The results showed that some pyrimidinone derivatives (1-6, 10, 11, 14, 15, 22-24, 26, and 27) could interact with the XIAP protein surface. In conclusion, these data suggest that some pyrimidinone derivatives can produce changes in the biological activity of XIAP. Therefore, these pyrimidinone derivatives could be good candidates to treat cancer.
UR  - https://ccij-online.org/article/analysis-of-interaction-between-twenty-seven-pyrimidinone-derivatives-with-xiap-using-a-theoretical-ujcfbpzjtzrsiym
ER  -